{"id":1715,"date":"2022-07-05T12:05:10","date_gmt":"2022-07-05T15:05:10","guid":{"rendered":"https:\/\/cib.udp.cl\/?post_type=publicacion&#038;p=1715"},"modified":"2023-07-19T18:38:45","modified_gmt":"2023-07-19T21:38:45","slug":"the-essential-oils-from-drymis-winteri-posses-potential-antioxidant-antimicrobial-antitumoral-activity-and-chemical-composition","status":"publish","type":"publicacion","link":"https:\/\/cib.udp.cl\/en\/publicacion\/the-essential-oils-from-drymis-winteri-posses-potential-antioxidant-antimicrobial-antitumoral-activity-and-chemical-composition\/","title":{"rendered":"The essential oils from\u00a0Drymis winteri\u00a0posses potential: antioxidant, antimicrobial, antitumoral activity and chemical composition."},"content":{"rendered":"<p>The Mapuche and their ancestors have used\u00a0<em>D. winteri<\/em>\u00a0in traditional medicine. In the present study, the essential oil extract of\u00a0<em>D. winteri<\/em>\u00a0leaves (DW_EO) were characterized chemically and biologically to evaluate its pharmacological activity.\u00a0<em>In vitro<\/em>\u00a0antioxidant activity was assayed, and antitumor activity was evaluated in non-tumor and tumor-cell culture lines.\u00a0<em>Caenorhabditis elegans<\/em>\u00a0was used as a model to evaluate toxicity, and the chemical composition of the essential oil was analyzed by gas chromatography-mass spectrometry. The chemical oil composition was characterized principally of five major terpenes: 4 sesquiterpenes \u03b3-Eudesmol (39.7%), \u03b2-Caryophyllene (33.7%), Elemol (25.9%), \u03b1-Eudesmol (0.3%) and 1 diterpene Kaunene (0.4%). By quantum calculations, it was determined that all oils have the ability to capture and yield electrons, which is consistent with the moderate antioxidant activity of DW_EO detected\u00a0<em>in vitro<\/em>. Furthermore, by molecular docking is estimated that these oils can bind to proteins involved in the production of oxygen radicals. Of these proteins, CYP2C9 could bind energetically, reaching binding energy between \u22126.8 and \u22129.2\u00a0kCal\/mol for the 5 terpenes studied, highlighting among these \u03b2-Caryophyllen and \u03b3-Eudesmol. DW_EO has effect against\u00a0<em>H. pylori<\/em>\u00a0(MIC 32\u00a0\u03bcg\/ml),\u00a0<em>S. aureus<\/em>\u00a0(MIC 8\u00a0\u03bcg\/ml),\u00a0<em>E. coli<\/em>\u00a0(MIC 32\u00a0\u03bcg\/ml) and\u00a0<em>C. albicans<\/em>\u00a0(MIC 64\u00a0\u03bcg\/ml), \u03b2-Caryophyllen and \u03b3 -Eudesmol (MIC 64\u00a0\u03bcg\/ml) and could selectively inhibit the proliferation of epithelial tumor cell lines but showed low against\u00a0<em>C. elegans<\/em>\u00a0(0.39\u20131.56\u00a0\u03bcg\u00a0mL<sup>\u22121<\/sup>). Therefore, DW_EO may be used as a source of bioactive compounds in novel pharmacological treatments for medical application, agronomics, sanitation, and food.<\/p>","protected":false},"featured_media":0,"template":"","class_list":["post-1715","publicacion","type-publicacion","status-publish","hentry","lineas-productos-naturales-y-sus-aplicaciones-en-el-control-de-patologias-humanas","revista-frontiers-in-natural-products"],"acf":[],"_links":{"self":[{"href":"https:\/\/cib.udp.cl\/en\/wp-json\/wp\/v2\/publicacion\/1715","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cib.udp.cl\/en\/wp-json\/wp\/v2\/publicacion"}],"about":[{"href":"https:\/\/cib.udp.cl\/en\/wp-json\/wp\/v2\/types\/publicacion"}],"wp:attachment":[{"href":"https:\/\/cib.udp.cl\/en\/wp-json\/wp\/v2\/media?parent=1715"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}