{"id":1731,"date":"2023-07-19T18:25:39","date_gmt":"2023-07-19T21:25:39","guid":{"rendered":"https:\/\/cib.udp.cl\/?post_type=publicacion&#038;p=1731"},"modified":"2023-07-19T18:25:58","modified_gmt":"2023-07-19T21:25:58","slug":"chemical-composition-antioxidant-antimicrobial-and-antiproliferative-activity-of-laureliopsis-philippiana-essential-oil-of-chile-study-in-vitro-and-in-silico","status":"publish","type":"publicacion","link":"https:\/\/cib.udp.cl\/en\/publicacion\/chemical-composition-antioxidant-antimicrobial-and-antiproliferative-activity-of-laureliopsis-philippiana-essential-oil-of-chile-study-in-vitro-and-in-silico\/","title":{"rendered":"Chemical composition, antioxidant, antimicrobial and antiproliferative activity of Laureliopsis philippiana essential oil of Chile, study in vitro and in silico"},"content":{"rendered":"<p>Chilean <em>Laureliopsis philippiana<\/em> has been used in traditional medicine by the Mapuche and their ancestors. To evaluate its pharmacological activity, <em>Laureliopsis philippiana<\/em> leaf essential oil extract (LP_EO) was chemically and biologically characterized in the present study. <em>In vitro<\/em> <a class=\"topic-link\" title=\"Learn more about antioxidant from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/antioxidant-agent\">antioxidant<\/a> potential was analyzed, and <a class=\"topic-link\" title=\"Learn more about antitumor activity from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/antitumor\">antitumor activity<\/a> was evaluated in non-tumor and tumor cell culture lines. <em>Caenorhabditis elegans<\/em> was used as a model for evaluating toxicity, and the chemical <a class=\"topic-link\" title=\"Learn more about composition from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/phase-composition\">composition<\/a> of the essential oil was analyzed using gas chromatography\u2013mass spectrometry. The oil contains six major <a class=\"topic-link\" title=\"Learn more about monoterpenes from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/monoterpene\">monoterpenes<\/a>: eucalyptol (27.7\u00a0%), <a class=\"topic-link\" title=\"Learn more about linalool from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/linalool\">linalool<\/a> (27.6\u00a0%), isozaphrol (19.5\u00a0%), isohomogenol (12.6\u00a0%), \u03b1-terpineol (7.7\u00a0%), and eudesmol (4.8\u00a0%). Based on quantum mechanical calculations, <a class=\"topic-link\" title=\"Learn more about isosafrole from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/isosafrole\">isosafrole<\/a> and isohomogenol conferred <em>in vitro<\/em> antioxidant and antimicrobial activity to LP_EO. In addition, LP_EO showed antimicrobial activity against clinical <em>Helicobacter pylori<\/em> isolates (MIC 64 and <a class=\"topic-link\" title=\"Learn more about MBC from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/mbc\">MBC<\/a>\u00a0&gt;\u00a0128\u00a0\u03bcg\u00b7mL<sup>\u22121<\/sup>), <em>Staphylococcus<\/em> aureus (MIC 32 and MBC\u00a0&gt;\u00a064\u00a0\u03bcg\u00b7mL<sup>\u22121<\/sup>), <em>Escherichia coli<\/em> (MIC 8 and MBC 16\u00a0\u03bcg\u00b7mL<sup>\u22121<\/sup>) and <em>Candida albicans<\/em>(MIC 64 and\u00a0&gt;\u00a0128\u00a0\u03bcg\u00b7mL<sup>\u22121<\/sup>). LP_EO could selectively inhibit the proliferation of epithelial tumor cell lines but showed low toxicity against <em>Caenorhabditis elegans<\/em> (0.39 to 1.56\u00a0\u03bcg\u00b7mL<sup>\u22121<\/sup>). Therefore, LP_EO may be used as a source of bioactive compounds in novel pharmacological treatments for veterinary and human application, cosmetics, or sanitation.<\/p>\n","protected":false},"featured_media":1732,"template":"","class_list":["post-1731","publicacion","type-publicacion","status-publish","has-post-thumbnail","hentry","lineas-productos-naturales-y-sus-aplicaciones-en-el-control-de-patologias-humanas","revista-arabian-journal-of-chemistry"],"acf":[],"_links":{"self":[{"href":"https:\/\/cib.udp.cl\/en\/wp-json\/wp\/v2\/publicacion\/1731","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cib.udp.cl\/en\/wp-json\/wp\/v2\/publicacion"}],"about":[{"href":"https:\/\/cib.udp.cl\/en\/wp-json\/wp\/v2\/types\/publicacion"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cib.udp.cl\/en\/wp-json\/wp\/v2\/media\/1732"}],"wp:attachment":[{"href":"https:\/\/cib.udp.cl\/en\/wp-json\/wp\/v2\/media?parent=1731"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}