{"id":976,"date":"2020-09-01T19:04:40","date_gmt":"2020-09-01T23:04:40","guid":{"rendered":"https:\/\/cib.udp.cl\/cms\/?post_type=publicacion&#038;p=976"},"modified":"2020-09-01T19:38:40","modified_gmt":"2020-09-01T23:38:40","slug":"absence-of-y-chromosome-microdeletions-in-patients-with-cryptorchidism-and-hypospadias","status":"publish","type":"publicacion","link":"https:\/\/cib.udp.cl\/en\/publicacion\/absence-of-y-chromosome-microdeletions-in-patients-with-cryptorchidism-and-hypospadias\/","title":{"rendered":"Absence of Y chromosome microdeletions in patients with cryptorchidism and hypospadias"},"content":{"rendered":"<p>Microdeletions of the Y chromosome have been observed in some patients with cryptorchidism and severe defects of spermatogenesis. We investigated whether microdeletions of the Y chromosome may be present in patients with cryptorchidism and hypospadias. Peripheral blood was obtained from 20 male patients 5.8 +\/- 4.1 years (range: 0.4-14 years) with cryptorchidism and hypospadias for somatic DNA analysis of Y chromosome using multiplex polymerase chain reaction. These patients had no identifiable genetic syndrome, other genitourinary malformations or an abnormal karyotype. We evaluated the presence or absence of amplification using a set of 34 different sequence-tagged sites (STS) in each patient. All patients showed normal length amplifications for each of the regions evaluated, suggesting that microdeletions of the Y chromosome are not a frequent cause of hypospadias associated with cryptorchidism.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-976","publicacion","type-publicacion","status-publish","hentry","lineas-bases-moleculares-y-genomicas-de-la-infertilidad","revista-journal-of-pediatric-endocrinology-and-metabolism"],"acf":[],"_links":{"self":[{"href":"https:\/\/cib.udp.cl\/en\/wp-json\/wp\/v2\/publicacion\/976","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cib.udp.cl\/en\/wp-json\/wp\/v2\/publicacion"}],"about":[{"href":"https:\/\/cib.udp.cl\/en\/wp-json\/wp\/v2\/types\/publicacion"}],"wp:attachment":[{"href":"https:\/\/cib.udp.cl\/en\/wp-json\/wp\/v2\/media?parent=976"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}