{"id":977,"date":"2020-09-01T19:07:16","date_gmt":"2020-09-01T23:07:16","guid":{"rendered":"https:\/\/cib.udp.cl\/cms\/?post_type=publicacion&#038;p=977"},"modified":"2020-09-01T19:38:27","modified_gmt":"2020-09-01T23:38:27","slug":"english-yqter-deletion-causes-arrest-of-spermatogenesis-in-early-puberty","status":"publish","type":"publicacion","link":"https:\/\/cib.udp.cl\/en\/publicacion\/english-yqter-deletion-causes-arrest-of-spermatogenesis-in-early-puberty\/","title":{"rendered":"YqTER deletion causes arrest of spermatogenesis in early puberty"},"content":{"rendered":"<p>We report a 12-7\/12 year-old male with obesity, eunuchoid proportions, genetic stigmata of Turner&#8217;s syndrome and mild developmental delay. We investigated whether cytogenetic alterations could be responsible for his phenotype. Conventional karyotype in 70 peripheral blood cells was 45,X(15%)\/46,XYqh-(85%). Dual FISH on 1,000 nuclei revealed 8% of X0 cells (DXZ1 X-centromeric probe) and 92% of XY cells (DYZ3 Y-centromeric probe). We studied Y chromosome microdeletions by PCR. The patient showed a terminal Yq deletion from the 5I interval including the AZFb and AZFc regions. FSH, LH and testosterone (468 ng\/dl) were within the normal range for his age. At Tanner IV pubertal development the spermiogram showed azoospermia and the testicular aspirate spermatic arrest. The present report suggests that Y chromosome deletions including AZFb and AZFc regions may cause spermatogenic arrest in early puberty.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-977","publicacion","type-publicacion","status-publish","hentry","lineas-bases-moleculares-y-genomicas-de-la-infertilidad","revista-journal-of-pediatric-endocrinology-and-metabolism"],"acf":[],"_links":{"self":[{"href":"https:\/\/cib.udp.cl\/en\/wp-json\/wp\/v2\/publicacion\/977","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cib.udp.cl\/en\/wp-json\/wp\/v2\/publicacion"}],"about":[{"href":"https:\/\/cib.udp.cl\/en\/wp-json\/wp\/v2\/types\/publicacion"}],"wp:attachment":[{"href":"https:\/\/cib.udp.cl\/en\/wp-json\/wp\/v2\/media?parent=977"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}