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Laboratory of Cellular Pathophysiology and Cancer

Lines of Research

Members

María Lorena Oróstica Arévalo

Associate Professor, Faculty

[email protected]

Projects

PROJECT

(Español) Factores asociados a obesidad e infertilidad favorecen el desarrollo y progresión de cáncer

Funding Source

PAI - ANID

2019-2022

Publications

PUBLICATION

Sperm utilize tumor necrosis factor alpha to shut down a 2-methoxyestradiol nongenomic pathway that accelerates oviductal egg transport in the rat

Journal

Reproduction

2023

PUBLICATION

(Español) Metformin Treatment Regulates the Expression of Molecules Involved in Adiponectin and Insulin Signaling Pathways in Endometria from Women with Obesity-Associated Insulin Resistance and PCOS

Journal

International Journal of Molecular Sciences

2022

PUBLICATION

(Español) Exosomes as therapy for cancer

Journal

Integrative Cancer Science and Therapeutics

2021

PUBLICATION

Pro-Inflammatory Markers Negatively Regulate IRS1 in Endometrial Cells and Endometrium from Women with Obesity and PCOS

Journal

Reproductive sciences

2020

PUBLICATION

The insulin-sensitizing mechanism of myo-inositol is associated with AMPK activation and GLUT-4 expression in human endometrial cells exposed to a PCOS environment

Journal

American Journal of physiology. Endocrinology and Metabolism.

2020

PUBLICATION

Effect of TNF-α on Molecules Related to the Insulin Action in Endometrial Cells Exposed to Hyperandrogenic and Hyperinsulinic Conditions Characteristics of Polycystic Ovary Syndrome

Journal

Reproductive sciences

2018

PUBLICATION

The nerve growth factor alters calreticulin translocation from the endoplasmic reticulum to the cell surface and its signaling pathway in epithelial ovarian cancer cells

Journal

International Journal of Oncology

2017

PUBLICATION

Role of Nerve Growth Factor (NGF) and miRNAs in Epithelial Ovarian Cancer

Journal

International Journal of Molecular Sciences

2017

PUBLICATION

Molecular Mechanisms of Androstenediol in the Regulation of the Proliferative Process of Human Endometrial Cells

Journal

Reproductive sciences

2017

PUBLICATION

Exosomes in bile as potential pancreatobiliary tumor biomarkers

Journal

Translational Cancer Research

2017

PUBLICATION

Prolactin gene expression in the pituitary of rats subjected to vaginocervical stimulation requires Erk-1/2 signaling

Journal

Reproductive Biology

2017

PUBLICATION

Altered Steroid Metabolism and Insulin Signaling in PCOS Endometria: Impact in Tissue Function

Journal

Current Pharmaceutical Design

2016

PUBLICATION

Proinflammatory environment and role of TNF-α in endometrial function of obese women having polycystic ovarian syndrome

Journal

International Journal of Obesity

2016

PUBLICATION

The role of mating in oviduct biology

Journal

Molecular Reproduction and Development

2016

PUBLICATION

Hyperandrogenism Decreases GRP78 Protein Level and Glucose Uptake in Human Endometrial Stromal Cells

Journal

Reproductive sciences

2016

PUBLICATION

Endometria from obese PCOS women with hyperinsulinemia exhibit altered adiponectin signaling

Journal

Hormone and Metabolic Research

2015

PUBLICATION

Estradiol increases IP3 by a nongenomic mechanism in the smooth muscle cells from the rat oviduct

Journal

Reproduction

2015

PUBLICATION

TNF-[alpha] and adiponectin pathways are deregulated in endometria from obese women with polycystic ovarian syndrome.

Journal

Endocrine Abstracts

2015

PUBLICATION

Mating decreases plasma levels of TGFb1 and regulates myosalpinx expression of TGFb1/TGFBR3 in the rat

Journal

Molecular Reproduction and Development

2014

PUBLICATION

Estradiol increases cAMP in the oviductal secretory cells through a nongenomic mechanism

Journal

Reproduction

2014

PUBLICATION

Changes in the gene expression pattern induced by 2-methoxyestradiol in the mouse uterus

Journal

Endocrine

2013

PUBLICATION

Tumour necrosis factor-α is the signal induced by mating to shutdown a 2-methoxyestradiol nongenomic action necessary to accelerate oviductal egg transport in the rat.

Journal

Reproduction

2013

PUBLICATION

Mating Effects on Female Reproductive Organs: The Paradigm of Estrogen Signaling Pathways in the Oviduct. En: Misaki Nakamura and Takako Ito, ed. Human and Animal Mating: Strategies, Gender Differences and Environmental Influences.

Journal

New York: Editorial Novinka

2013

PUBLICATION

A non-genomic signaling pathway shut down by mating changes the estradiol-induced gene expression profile in the rat oviduct

Journal

Reproduction

2010

PUBLICATION

TNF-Alpha and TGF-Beta Signaling Cascades are Associated with the Changes in the Mode of Action of Estradiol in the Rat Oviduct

Journal

Biology of Reproduction

2009