
We investigate those mechanisms that trigger molecular, cellular and behavioral changes in different models of neuropsychiatric pathologies.
We study the degeneration and protection of the dopaminergic system (including Parkinson’s disease), the effect of chronic stress in intrauterine and postnatal stages of development, Alzheimer’s disease and drug addiction.
Fish Oil Supplementation Attenuates Offspring’s Neurodevelopmental Changes Induced by a Maternal High-Fat Diet in a Rat Model
Journal
Nutrients2025
Women with polycystic ovary syndrome (PCOS): Likelihood of cooccurring neuropsychiatric conditions and the dual hit hypothesis
Journal
Frontiers in Neuroendocrinology2025
New Players in Neuronal Iron Homeostasis: Insights from CRISPRi Studies
Journal
Antioxidants (Basel)2022
Behavioral effects of aminochrome and dopachrome injected in the rat substantia nigra
Journal
Pharmacology, Biochemistry and Behavior2002
DT-diaphorase: A neuroprotective enzyme of dopaminergic systems
Journal
Polish Journal of Pharmacology2002
Anatomy of “mesencephalic” dopaminergic cell groups in the central nervous system.
Journal
Mechanism of Degeneration and Protection of the Dopaminergic System (J. Segura-Aguilar, Ed.) F.P. Graham, New York2001
Dendritic structure of single hippocampal neurons according to sex and hemisphere of origin in middle-aged and elderly human subjects
Journal
Brain Research2001
Chronic stress decreases the expression of sympathetic markers in the pineal gland and increases plasma melatonin concentration in rats
Journal
Journal of neurochemistry2006
Human-like rodent amyloid-beta-peptide determines Alzheimer pathology in aged wild-type Octodon degu
Journal
Neurobiology of Aging2005
Behavioral effects of manganese injected in the rat substantia nigra are potentiated by dicumarol, a DT-diaphorase inhibitor
Journal
Pharmacology, Biochemistry and Behavior2004
AChE-rich magnopyramidal neurons have a left-right size asymmetry in Broca’s area
Journal
Brain Research2004
Prenatal stress down-regulates Reelin expression by methylation of its promoter and induces adult behavioral impairments in rats
Journal
Plos One2015
Cerebellum-Like Artificial Neural Networks bioinspired on cerebellum neural architecture at multiple levels of complexity (CLANN)
Funding Source
SticAmsud -ANID2022-2025
Impact of the high n-6 polyunsaturated fatty acid intake and/or maternal obesity on neurodevelopment. Is there an essential contribution of dietary n-3 fatty acids?
Funding Source
Fondecyt2022-2026
Hyperandrogenism during prenatal and pubertal development alters functional brain networks compromising social cognition in daughters of women with Polycystic Ovary Syndrome: a double hit hypothesis
Funding Source
Fondecyt2021-2025
Indole Alkaloid sub products of Maqui (Aristotelia chilensis) processing as food additives to Alzheimer’s disease treatment
Funding Source
FAPESP2018-2021