Investigamos aquellos mecanismos que gatillan cambios moleculares, celulares y conductuales en distintos modelos de patologías neuropsiquiátricas.
Estudiamos la degeneración y protección del sistema dopaminérgico (incluyendo enfermedad de Parkinson), el efecto de estrés crónico en etapas del desarrollo intrauterino y postnatales, la enfermedad de Alzheimer y la adicción a drogas.
New Players in Neuronal Iron Homeostasis: Insights from CRISPRi Studies
Revista
Antioxidants (Basel)2022
Behavioral effects of aminochrome and dopachrome injected in the rat substantia nigra
Revista
Pharmacology, Biochemistry and Behavior2002
DT-diaphorase: A neuroprotective enzyme of dopaminergic systems
Revista
Polish Journal of Pharmacology2002
Anatomy of “mesencephalic” dopaminergic cell groups in the central nervous system
Revista
Mechanism of Degeneration and Protection of the Dopaminergic System (J. Segura-Aguilar, Ed.) F.P. Graham, New York2001
Dendritic structure of single hippocampal neurons according to sex and hemisphere of origin in middle-aged and elderly human subjects
Revista
Brain Research2001
Chronic stress decreases the expression of sympathetic markers in the pineal gland and increases plasma melatonin concentration in rats
Revista
Journal of neurochemistry2006
Human-like rodent amyloid-beta-peptide determines Alzheimer pathology in aged wild-type Octodon degu
Revista
Neurobiology of Aging2005
Behavioral effects of manganese injected in the rat substantia nigra are potentiated by dicumarol, a DT-diaphorase inhibitor
Revista
Pharmacology, Biochemistry and Behavior2004
AChE-rich magnopyramidal neurons have a left-right size asymmetry in Broca’s area
Revista
Brain Research2004
Prenatal stress down-regulates Reelin expression by methylation of its promoter and induces adult behavioral impairments in rats
Revista
Plos One2015
Cerebellum-Like Artificial Neural Networks bioinspired on cerebellum neural architecture at multiple levels of complexity (CLANN)
Fuente de Financiamiento
SticAmsud -ANID2022-2025
Impact of the high n-6 polyunsaturated fatty acid intake and/or maternal obesity on neurodevelopment. Is there an essential contribution of dietary n-3 fatty acids?
Fuente de Financiamiento
Fondecyt2022-2026
Hyperandrogenism during prenatal and pubertal development alters functional brain networks compromising social cognition in daughters of women with Polycystic Ovary Syndrome: a double hit hypothesis
Fuente de Financiamiento
Fondecyt2021-2025
Alcaloides indólicos, subproductos del procesamiento del Maqui (Aristotelia chilensis) como aditivos alimenticios para el tratamiento de la Enfermedad de Alzheimer
Fuente de Financiamiento
FAPESP2018-2021